# NIOSH Pocket Guide to Chemical Hazards
Isophorone diisocyanate | CAS 4098-71-9
C12H18N2O2 | RTECS NQ9370000
Synonyms & Trade Names IPDI; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl-isocyanate; Isophorone diamine diisocyanate | DOT ID & Guide 2290 156
Exposure Limits | NIOSH REL: TWA 0.005 ppm (0.045 mg/m3) ST 0.02 ppm (0.180 mg/m3) [skin]
OSHA PEL†: none
IDLH N.D. | Conversion 1 ppm = 9.09 mg/m3
Physical Description Colorless to slightly yellow liquid with a pungent odor.
MW: 222.3 | BP: ? | FRZ: -76°F | Sol: Decomposes
VP: 0.0003 mmHg | IP: ? |  | Sp.Gr: 1.06
Fl.P: 311°F | UEL: ? | LEL: ? |
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Incompatibilities & Reactivities Water, alcohols, phenols, amines, mercaptans, amides, urethanes, ureas [Note: Reacts with water to form carbon dioxide.]
Measurement Methods OSHA PV2034
Personal Protection & Sanitation Skin: Prevent skin contact Eyes: Prevent eye contact Wash skin: When contaminated Remove: When wet or contaminated Change: Daily Provide: Quick drench | First Aid (See procedures) Eye: Irrigate immediately Skin: Water flush immediately Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH Up to 0.05 ppm: (APF = 10) Any supplied-air respirator* Up to 0.125 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode* Up to 0.25 ppm: (APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece Up to 1 ppm: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, respiratory system; chest tightness, dyspnea (breathing difficulty), cough, sore throat; bronchitis, wheezing, pulmonary edema; possible respiratory sensitization, asthma
Target Organs Eyes, skin, respiratory system
See also: INTRODUCTION