# NIOSH Pocket Guide to Chemical Hazards
Tetramethyl lead (as Pb) | CAS 75-74-1
Pb(CH3)4 | RTECS TP4725000
Synonyms & Trade Names Lead tetramethyl, Tetramethylplumbane, TML | DOT ID & Guide
Exposure Limits | NIOSH REL: TWA 0.075 mg/m3 [skin]
OSHA PEL: TWA 0.075 mg/m3 [skin]
IDLH 40 mg/m3 (as Pb) | Conversion
Physical Description Colorless liquid (unless dyed red, orange, or blue) with a fruity odor. [Note: Main usage is in anti-knock additives for gasoline.]
MW: 267.3 | BP: 212°F (Decomposes) | FRZ: -15°F | Sol: 0.002%
VP: 23 mmHg | IP: 8.50 eV |  | Sp.Gr: 2.00
Fl.P: 100°F | UEL: ? | LEL: ? |
Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.
Incompatibilities & Reactivities Strong oxidizers such as sulfuryl chloride or potassium permanganate
Measurement Methods NIOSH 2534
Personal Protection & Sanitation Skin: Prevent skin contact (>0.1%) Eyes: Prevent eye contact Wash skin: When contaminated (>0.1%) Remove: When wet or contaminated (>0.1%) Change: Daily Provide: Quick drench (>0.1%) | First Aid (See procedures) Eye: Irrigate immediately Skin: Soap wash immediately Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH/OSHA Up to 0.75 mg/m3: (APF = 10) Any supplied-air respirator Up to 1.875 mg/m3: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode Up to 3.75 mg/m3: (APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece Up to 40 mg/m3: (APF = 1000) Any supplied-air respirator operated in a pressure-demand or other positive-pressure mode Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure- demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Insomnia, bad dreams, restlessness, anxious; hypotension; nausea, anorexia; delirium, mania, convulsions; coma
Target Organs central nervous system, cardiovascular system, kidneys
See also: INTRODUCTION