# NIOSH Pocket Guide to Chemical Hazards
Toluenediamine | CAS 25376-45-8 95-80-7 (2,4-TDA)
CH3C6H3(NH2)2 | RTECS XS9445000 XS9625000 (2,4-TDA)
Synonyms & Trade Names Diaminotoluene, Methylphenylene diamine, TDA, Toluenediamine isomers, Tolylenediamine [Note: Various isomers of TDA exist.] | DOT ID & Guide 1709 151
Exposure Limits | NIOSH REL: Ca (all isomers) See Appendix A
OSHA PEL: none
IDLH Ca [N.D.] | Conversion
Physical Description Colorless to brown, needle-shaped crystals or powder. [Note: Tends to darken on storage & exposure to air. Properties given are for 2,4-TDA.]
MW: 122.2 | BP: 558°F | MLT: 210°F | Sol: Soluble
VP(224°F): 1 mmHg | IP: ? |  | Sp.Gr: 1.05 (Liquid at 212°F)
Fl.P: 300°F | UEL: ? | LEL: ? |
Combustible Solid
Incompatibilities & Reactivities None reported
Measurement Methods NIOSH 5516; OSHA 65
Personal Protection & Sanitation Skin: Prevent skin contact Eyes: Prevent eye contact Wash skin: When contaminated/Daily Remove: When wet or contaminated Change: Daily Provide: Eyewash, Quick drench | First Aid (See procedures) Eye: Irrigate immediately Skin: Water flush immediately Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; dermatitis; ataxia, tachycardia, nausea, vomiting, convulsions, respiratory depression; methemoglobinemia, cyanosis, headache, lassitude (weakness, exhaustion), dizziness, bluish skin; liver injury; [potential occupational carcinogen]
Target Organs Eyes, skin, respiratory system, blood, cardiovascular system, liver Cancer Site [in animals: liver, skin & mammary gland tumors]
See also: INTRODUCTION