# NIOSH Pocket Guide to Chemical Hazards
Methyl isoamyl ketone | CAS 110-12-3
CH3COCH2CH2CH(CH3)2 | RTECS MP3850000
Synonyms & Trade Names Isoamyl methyl ketone, Isopentyl methyl ketone, 2-Methyl-5-hexanone, 5-Methyl-2-hexanone, MIAK | DOT ID & Guide 2302 127
Exposure Limits | NIOSH REL: TWA 50 ppm (240 mg/m3)
OSHA PEL†: TWA 100 ppm (475 mg/m3)
IDLH N.D. | Conversion 1 ppm = 4.67 mg/m3
Physical Description Colorless, clear liquid with a pleasant, fruity odor.
MW: 114.2 | BP: 291°F | FRZ: -101°F | Sol: 0.5%
VP: 5 mmHg | IP: 9.284 eV |  | Sp.Gr: 0.81
Fl.P: 97°F | UEL(200°F): 8.2% | LEL(200°F): 1.0% |
Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.
Incompatibilities & Reactivities Oxidizers
Measurement Methods OSHA PV2042
Personal Protection & Sanitation Skin: Prevent skin contact Eyes: Prevent eye contact Wash skin: When contaminated Remove: When wet (flammable) Change: No recommendation | First Aid (See procedures) Eye: Irrigate immediately Skin: Soap flush promptly Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH Up to 500 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*/(APF = 10) Any supplied-air respirator* Up to 1250 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode*/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)* Up to 2500 ppm: (APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*/(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece Up to 5000 ppm: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, mucous membrane; headache, narcosis, coma; dermatitis; in animals: liver, kidney damage
Target Organs Eyes, skin, respiratory system, central nervous system, liver, kidneys
See also: INTRODUCTION