# NIOSH Pocket Guide to Chemical Hazards
Diisobutyl ketone | CAS 108-83-8
[(CH3)2CHCH2]2CO | RTECS MJ5775000
Synonyms & Trade Names DIBK; sym-Diisopropyl acetone; 2,6-Dimethyl-4-heptanone; Isovalerone; Valerone | DOT ID & Guide 1157 127
Exposure Limits | NIOSH REL: TWA 25 ppm (150 mg/m3)
OSHA PEL†: TWA 50 ppm (290 mg/m3)
IDLH 500 ppm | Conversion 1 ppm = 5.82 mg/m3
Physical Description Colorless liquid with a mild, sweet odor.
MW: 142.3 | BP: 334°F | FRZ: -43°F | Sol: 0.05%
VP: 2 mmHg | IP: 9.04 eV |  | Sp.Gr: 0.81
Fl.P: 120°F | UEL(200°F): 7.1% | LEL(200°F): 0.8% |
Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.
Incompatibilities & Reactivities Strong oxidizers
Measurement Methods NIOSH 1300; OSHA 7
Personal Protection & Sanitation Skin: Prevent skin contact Eyes: No recommendation Wash skin: When contaminated Remove: When wet or contaminated Change: No recommendation | First Aid (See procedures) Eye: Irrigate immediately Skin: Soap wash promptly Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH Up to 500 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode£/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)£/(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; headache, dizziness; dermatitis; liver, kidney damage
Target Organs Eyes, skin, respiratory system, central nervous system, liver, kidneys
See also: INTRODUCTION