# NIOSH Pocket Guide to Chemical Hazards
Isobutyronitrile | CAS 78-82-0
(CH3)2CHCN | RTECS TZ4900000
Synonyms & Trade Names Isopropyl cyanide, 2-Methylpropanenitrile, 2-Methylpropionitrile | DOT ID & Guide 2284 131
Exposure Limits | NIOSH REL: TWA 8 ppm (22 mg/m3)
OSHA PEL: none
IDLH N.D. | Conversion 1 ppm = 2.83 mg/m3
Physical Description Colorless liquid with an almond-like odor. [Note: Forms cyanide in the body.]
MW: 69.1 | BP: 219°F | FRZ: -97°F | Sol: Slight
VP(130°F): 100 mmHg | IP: ? |  | Sp.Gr: 0.76
Fl.P: 47°F | UEL: ? | LEL: ? |
Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.
Incompatibilities & Reactivities Oxidizers, reducing agents, strong acids & bases
Measurement Methods NIOSH 1606 (adapt)
Personal Protection & Sanitation Skin: Prevent skin contact Eyes: Prevent eye contact Wash skin: When contaminated Remove: When wet (flammable) Change: No recommendation Provide: Eyewash, Quick drench | First Aid (See procedures) Eye: Irrigate immediately Skin: Soap flush immediately Breathing: Respiratory support Swallow: Medical attention immediately
Respirator Recommendations NIOSH Up to 80 ppm: (APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)/(APF = 10) Any supplied-air respirator Up to 200 ppm: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode/(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s) Up to 400 ppm: (APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)/(APF = 50) Any self-contained breathing apparatus with a full facepiece/(APF = 50) Any supplied-air respirator with a full facepiece Up to 1000 ppm: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode Emergency or planned entry into unknown concentrations or IDLH conditions: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus Escape: (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus
Exposure Routes inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms Irritation eyes, skin, nose, throat; headache, dizziness, lassitude (weakness, exhaustion), confusion, convulsions; dyspnea (breathing difficulty); abdominal pain, nausea, vomiting
Target Organs Eyes, skin, respiratory system, central nervous system, cardiovascular system
See also: INTRODUCTION